מכונים

יצירת קשר

​שולה: 04-6494399, 050-5812509
goez_s@clalit.org.il
נטשה: 04-6494575, 054-7645266
natalia_ed@clalit.org.il     

שעות פעילות

​א'-ה' 8:00-16:00

מיקום

​בניין מספר 3, בניין אשפוז וחדרי ניתוח, קומת מרתף

TMA

מנהלת המכון: ד"ר אירית אלמלח

Tissue Microarray (TMA): a revolution in Tissue - based research​

ABSTRACT

Tissue microarray (TMA) is a recent innovation in the field of pathology, which is now available in Tissue Diagnostic and Cancer Research Institute, Emek Medical Center. Nowadays this automated technique became a favorite tool in tissue diagnostic researches. Most studies on tissues, deal with proteins identification using immunohistochemistry and immunofluorescence, which utilize the main part of the research budget. TMA module reduces the immunostain's cost in hundreds percent, by including many tissues samples on one slide. The TMA system (3DHISTECH) includes TMA Grand Master, Scanner and analytical softwares which allow a significant reduction in cost and time together with a major improvement of accuracy and quality.

What is TMA?

A tissue microarray contains many small representative tissue samples from hundreds of different cases assembled on a single histologic block/slide, and therefore allows high throughput analysis of multiple specimens at the same time. Tissue microarrays are paraffin blocks produced by extracting cylindrical tissue cores from different paraffin donor blocks and re-embedding these into a single recipient (microarray) block at defined array coordinates. Using this technique, hundreds of tissue samples can be presented onto a single slide for all kind of stains.

What are the parts of the TMA system?

TMA Grand Master

TMA Grand Master has world’s highest capacity of 72 blocks - 60 donor blocks at the same time and 12 recipient blocks. 4 different core diameters can be chosen by the researcher: 0.6 mm, 1 mm, 1.5 mm and 2 mm. The core sampling takes max. 12 seconds per core due to simultaneous loading, imaging, drilling and punching.

tma grand master.jpg 


TMA Scanner- Pannoramic MIDI

The Pannoramic MIDI has a capacity of 12 slides which can be scanned in brightfield or up to 9-channel fluorescent scanning using monochrome camera for high quality. The loading, previewing barcode reading and scanning is automated.


TMA Scanner- Pannoramic MIDI.png 

TMA CASECENTER

The TMA casecenter is a server which allows data collection, storage and maintenance and collaboration with remote resea.

TMA CASECENTER.png 

How it works? 

how it works.png 

What are the advantages of the TMA system?

save

 Reagent

 Time

Tissue

Workforce

 Decreased assay volume

Allow

Standardized laboratory conditions through automation

Central data handling

Simultaneous analyses of very large numbers of specimens

TMA technique conserves valuable tissue for further studies ad diagnosis

Allows formation of digital database of slides and images

 High quality brightfield and fluorescent images

External links for additional information

Pannoramic MIDI II

TMA Grand Master

QuantCenter

TMA chart.jpg 

 

for more information