כללית שלי
מרכז רפואי כרמל, חיפה

פרופ' גד רנרט

מנהל המחלקה לרפואת הקהילה ואפידמיולוגיה

פרטים אישיים

פרופ' גד רנרט
  • תפקידים ומינויים

    מנהל המרכז הארצי לבקרת סרטן והתוכנית לרפואה מותאמת אישית בכללית
    מנהל המחלקה לרפואת הקהילה ואפידמיולוגיה

  • התמחות

    בריאות הציבור ורפואה מונעת
    גנטיקה של סרטן
    רפואה מותאמת אישית
    רפואה גנומית

  • פרסומים נבחרים

    1.      Michailidou K, Lindström S, Dennis J, et al. Association analysis identifies 65 new breast cancer risk loci. Nature. 2017 Nov 2;551(7678):92-94. doi: 10.1038/nature24284. Epub 2017 Oct 23.

    2.       Li Y, Xiao X, Han Y, et al. Genome-wide interaction study of smoking behavior and non-small cell lung cancer risk in Caucasian population. Carcinogenesis. 2017 Oct 20. doi: 10.1093/carcin/bgx113. [Epub ahead of print]

    3.       Milne RL, Kuchenbaecker KB, Michailidou K, et al.  Identification of ten variants associated with risk of estrogen-receptor-negative breast cancer. Nat Genet. 2017 Dec;49(12):1767-1778. doi: 10.1038/ng.3785. Epub 2017 Oct 23.

    4.       Wang T, Moon JY, Wu Y, et al. Pleiotropy of genetic variants on obesity and smoking phenotypes: Results from the Oncoarray Project of The International Lung Cancer Consortium. PLoS One. 2017 Sep 28;12(9):e0185660. doi: 10.1371/journal.pone.0185660.

    5.       Carreras-Torres R, Johansson M, Haycock PC, et al.. Obesity, metabolic factors and risk of different histological types of lung cancer: A Mendelian randomization study. PLoS One. 2017 Jun 8;12(6):e0177875.

    6.       Rennert G. Handling Individuals with High Cancer Risk: One Size Doesn't Fit All. Isr Med Assoc J. 2016 Sep;18(9):567-568.

    7.       Gronich N, Lavi I, Barnett-Griness O, Saliba W, Abernethy DR, Rennert G. Tyrosine kinase-targeting drugs-associated heart failure. Br J Cancer. 2017 May 9;116(10):1366-1373.

    8.       Phelan CM, Kuchenbaecker KB, Tyrer JP, et al. Identification of 12 new susceptibility loci for different histotypes of epithelial ovarian cancer. Nat Genet. 2017 May;49(5):680-691.

    9.       Maoz A, Rennert G, Gruber SB. T-Cell Transfer Therapy Targeting Mutant KRAS. N Engl J Med. 2017 Feb 16;376(7):e11.

    10.    Saliba W, Barnett-Griness O, Rennert G. Red cell distribution width and all-cause mortality in patients with atrial fibrillation: A cohort study. J Arrhythm. 2017 Feb;33(1):56-62.

    11.    Saliba W, Schliamser JE, Lavi I, Barnett-Griness O, Gronich N, Rennert G. Catheter ablation of atrial fibrillation is associated with reduced risk of stroke and mortality: A propensity score-matched analysis. Heart Rhythm. 2017 Feb 9. pii: S1547-5271(17)30159-5.

    12.    Preis M, Hirsch J, Kotler A, Zoabi A, Stein N, Rennert G, Saliba W. Factor XI deficiency is associated with decreased risk for cardiovascular and venous thromboembolism events. Blood. 2016 Dec 30. pii: blood-2016-09-742262. [Epub ahead of print]

    13.    Fehringer G, Brenner DR, Zhang ZF, et al. Alcohol and lung cancer risk among never smokers: A pooled analysis from the international lung cancer consortium and the SYNERGY study. Int J Cancer. 2017 May 1;140(9):1976-1984

    14.    Rennert G. Reproductive factors, hormones and colorectal cancer-still unresolved. Br J Cancer. 2016 Nov 29. doi: 10.1038/bjc.2016.388.

    15.    Vijai J, Topka S, Villano D, et al. A Recurrent ERCC3 Truncating Mutation Confers Moderate Risk for Breast Cancer. Cancer Discov. 2016 Nov;6(11):1267-1275.

    16.    Hamdi Y, Soucy P, Kuchenbaeker KB, et al.  Association of breast cancer risk in BRCA1 and BRCA2 mutation carriers with genetic variants showing differential allelic expression: identification of a modifier of breast cancer risk at locus 11q22.3. Breast Cancer Res Treat. 2016 Oct 28.

    17.    Rennert G, Pinchev M, Gronich N, et al. Oral bisphosphonates and improved survival of breast cancer. Clin Cancer Res. 2016 Sep 28. pii:clincanres.0547.2016. [Epub ahead of print]

    18.    Hagoel L, Neter E, Stein N, Rennert G. Harnessing the Question-Behavior Effect to Enhance Colorectal Cancer Screening in an mHealth Experiment. Am J Public Health. 2016 Nov;106(11):1998-2004.

    19.    Lawrenson K, Kar S, McCue K, et al. Functional mechanisms underlying pleiotropic risk alleles at the 19p13.1 breast-ovarian cancer susceptibility locus. Nat Commun. 2016 Sep 7;7:12675.

    20.    Vigorito E, Kuchenbaecker KB, Beesley J, et al. Fine-Scale Mapping at 9p22.2 Identifies Candidate Causal Variants That Modify Ovarian Cancer Risk in BRCA1 and BRCA2 Mutation Carriers. PLoS One. 2016 Jul 27;11(7):e0158801.

    21.    Schmit SL, Rennert HS, Rennert G, Gruber SB. Coffee Consumption and the Risk of Colorectal Cancer. Cancer Epidemiol Biomarkers Prev. 2016 Apr;25(4):634-9.

    22.    Rozek LS, Schmit SL, Greenson JK, et al. Tumor-Infiltrating Lymphocytes, Crohn's-Like Lymphoid Reaction, and Survival From Colorectal Cancer. J Natl Cancer Inst. 2016 May 12;108(8). pii: djw027.

    23.    Couch FJ, Kuchenbaecker KB, Michailidou K, et al. Identification of four novel susceptibility loci for oestrogen receptor negative breast cancer. Nat Commun. 2016 Apr 27;7:11375.

    24.    Dunning AM, Michailidou K, Kuchenbaecker KB, et al. Breast cancer risk variants at 6q25 display different phenotype associations and regulate ESR1, RMND1 and CCDC170. Nat Genet. 2016 Feb 29.

    25.    Huang R, Wei Y, Hung RJ, et al. Associated Links Among Smoking, Chronic Obstructive Pulmonary Disease, and Small Cell Lung Cancer: A Pooled Analysis in the International Lung Cancer Consortium.  EBioMedicine. 2015 Sep 24;2(11):1677-1685.

    26.    Markowitz SD, Nock NL, Schmit SL, et al.  A Germline Variant on Chromosome 4q31.1 Associates with Susceptibility to Developing Colon Cancer Metastasis. PLoS One. 2016 Jan 11;11(1):e0146435.

    27.    Schumacher FR, Schmit SL, Jiao S, et al. Genome-wide association study of colorectal cancer identifies six new susceptibility loci. Nat Commun. 2015 Jul 7;6:7138.

    28.    Manolio TA, Abramowicz M, Al-Mulla F, et al. Global implementation of genomic medicine: We are not alone. Sci Transl Med. 2015 Jun 3;7(290):290ps13.

    29.    Rennert G, Kremer R, Rennert HS, et al. Lower lung cancer rates in Jewish smokers in Israel and the USA. Int J Cancer. 2015 Nov 1;137(9):2155-62.

    30.    Kuchenbaecker KB, Ramus SJ, Tyrer J, et al. Identification of six new susceptibility loci for invasive epithelial ovarian cancer. Nat Genet. 2015 Feb;47(2):164-71.

    31.    Leitner-Dagan Y, Sevilya Z, Pinchev M, et al. Enzymatic MPG DNA repair assays for two different oxidative DNA lesions reveal associations with increased lung cancer risk. Carcinogenesis. 2014 Dec;35(12):2763-70.

    32.    Sevilya Z, Leitner-Dagan Y, Pinchev M, et al. Low integrated DNA repair score and lung cancer risk. Cancer Prev Res . 2014;4:398-406.

    33.    Gronich N, Rennert G. Beyond aspirin-cancer prevention with statins, metformin and bisphosphonates. Nat Rev Clin Oncol. 2013;10(11):625-42.

    34.    Couch FJ, Wang X, McGuffog L, et al. Genome-wide association study in BRCA1 mutation carriers identifies novel loci associated with breast and ovarian cancer risk. PLoS Genet. 2013;9(3):e1003212.

    35.    Gaudet MM, Kuchenbaecker KB, Vijai J, et al. Identification of a BRCA2-specific modifier locus at 6p24 related to breast cancer risk. PLoS Genet. 2013;9(3):e1003173.

    36.    Coté ML, Liu M, Bonassi S, et al. Increased risk of lung cancer in individuals with a family history of the disease: a pooled analysis from the International Lung Cancer Consortium. Eur J Cancer. 2012;48(13):1957-68.

    37.    Rennert G. Bisphosphonates: beyond prevention of bone metastases. J Natl Cancer Inst. 2011;103(23):1728-9.

    38.    Sanz-Pamplona R, Cordero D, Berenguer A, et al. Gene expression differences between colon and rectum tumors. Clin Cancer Res. 2011;17(23):7303-12.

    39.    McCormack VA, Hung RJ, Brenner DR, et al. Aspirin and NSAID use and lung cancer risk: a pooled analysis in the International Lung Cancer Consortium (ILCCO). Cancer Causes Control. 2011 Dec;22(12):1709-20.

    40.    Rennert G, Lejbkowicz F, Cohen I, et al. MutYH mutation carriers have increased breast cancer risk. Cancer. 2012;118(8):1989-93.

    41.    Rennert G, Pinchev M, Rennert HS, Gruber SB. Use of bisphosphonates and reduced risk of colorectal cancer. J Clin Oncol. 2011;29(9):1146-50.

    42.    Truong T, Hung RJ, Amos CI, et al. Replication of lung cancer susceptibility loci at chromosomes 15q25, 5p15, and 6p21: a pooled analysis from the International Lung Cancer Consortium. J Natl Cancer Inst. 2010 Jul 7;102(13):959-71.

    43.    Gaudet MM, Kirchhoff T, Green T, et al. Common genetic variants and modification of penetrance of BRCA2-associated breast cancer. PLoS Genet. 2010;6(10):e1001183.

    44.    Antoniou AC, Beesley J, McGuffog L, et al. Common breast cancer susceptibility alleles and the risk of breast cancer for BRCA1 and BRCA2 mutation carriers: implications for risk prediction. Cancer Res. 2010;70(23):9742-54.

    45.    Antoniou AC, Wang X, Fredericksen ZS, et al. A locus on 19p13 modifies risk of breast cancer in BRCA1 mutation carriers and is associated with hormone receptor-negative breast cancer. Nat Genet. 2010;42(10):885-92.

    46.    Rennert G, Pinchev M, Rennert HS. Use of bisphosphonates and risk of postmenopausal breast cancer. J Clin Oncol. 2010;28(22):3577-81.

    47.    Rennert G, Rennert HS, Pinchev M, Gruber SB. A case-control study of levothyroxine and the risk of colorectal cancer. J Natl Cancer Inst. 2010;102(8):568-72.

    48.    Rennert G, Rennert HS, Pinchev M, et al. Use of hormone replacement therapy and the risk of colorectal cancer. J Clin Oncol. 2009;27(27):4542-7.

    49.    Raskin L, Lejbkowicz F, Barnett-Griness O, et al. BRCA1 breast cancer risk is modified by CYP19 polymorphisms in Ashkenazi Jews. Cancer Epidemiol Biomarkers Prev. 2009;18(5):1617-23.

    50.    Khoury-ShakourS, Gruber SB, Lejbkowicz F,et al.Recreational physical activity modifies the association between a common GH1 polymorphism and colorectal cancer risk. Cancer Epidemiol Biomarkers Prev. 2008;17(12):3314-8.

    51.    Raskin L, Pinchev M, Arad C, et al. FGFR2 is a breast cancer susceptibility gene in Jewish and Arab Israeli populations. Cancer Epidemiol Biomarkers Prev. 2008;17(5):1060-5.

    52.    Rennert G, Bisland-Naggan S, Barnett-Griness O, et al. Clinical outcomes of breast cancer in carriers of BRCA1 and BRCA2 mutations. N Engl J Med. 2007;357(2):115-23.

    53.    Rennert G. Are we taking the right approach in planning chemoprevention studies? Nat Clin Pract Oncol 2006;3:464-5.

    54.    Poynter JN, Gruber SB, Higgins PD, Rennert HS,  Rennert G. Statins and the risk of colorectal cancer. N Engl J Med 2005;352(21):2184-92.

    55.    Gruber SB, Ellis NA, Scott KK, et al.. BLM heterozygosity and the risk of colorectal cancer. Science 2002;297(5589):2013.

  • פעילות אקדמית

    פרופסור מן המניין וראש החוג לבריאות הציבור / רפואה מונעת בפקולטה לרפואה, הטכניון.