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יצירת קשר

פרופ' מיקי רהט
טלפון: 04-8250404
דוא"ל:  rahat_miki@clalit.org.il
mrahat@technion.ac.il

אתר המעבדה

​http://rahat-lab.net.technion.ac.il/

מעבדה לאימונותרפיה

מנהלת המעבדה פרופ' מיקי רהט

המעבדה לאימונותרפיה

תחומי מחקר עיקריים: 

  1. החלבון EMMPRIN כמתווך של אינטראקציות בין מקרופאג'ים ותאי סרטן ושל תהליך האנגיוגנזה. 

  2. פיתוח אימונותרפיה (חיסון סביל ופעיל) כנגד EMMPRIN

  3. תפקידה של microRNA-146a-5p בבקרה על ביטוי EMMPRIN.  

  4. EMMPRIN ו-microRNA כסמנים ביולוגיים להערכת מצבם הדלקתי של חולים. 

​רשימת פרסומים נבחרים: 

Books

  1. Rahat MA, Coffelt SB, Granot Z, Muthana M, and Amedei A. (eds.) Macrophages and Neutrophils: Regulation of the Inflammatory Microenvironment in Autoimmunity and Cancer. Mediators of Inflammation, 2016 (eBook).

  2. Rahat MA, Hemmerlein B, and Iragavarapu-Charyulu V. (eds.). The regulation of angiogenesis by tissue cell-macrophage interactions. Frontiers in Physiology, 2014 (eBook).

 

Papers: 

  1. Rahat MA.  Targeting angiogenesis with peptide vaccines. Frontiers in Immunology 10: article 1924, 11 pages, 2019.

  2. Hoffman E*, Rahat MA*, Feld J, Elias M, Rosner I, Kaly L, Lavie I, Gazitt T,  and Zisman D. Effects of tocilizumab, an anti-interleukin-6 receptor antibody, on serum lipid and adipokine levels in patients with rheumatoid arthritis. International Journal of Molecular Sciences, 2019; 20(18): 4633-4644.

  3. Feld J,  Nissan S, Eder L, Rahat MA, Elias E, Rimar D, Laor A, Bitterman H, Zisman D. Increased prevalence of metabolic syndrome and adipocytokine levels in a psoriatic arthritis cohort. Journal of Clinical Rheumatology, 2018; 24(6):302-307

  4. Simanovich E, Brod V, Rahat MM, and Rahat MA. Function of miR-146a-5p in tumor cells as a regulatory switch between death and angiogenesis: macrophage therapy revisited. Frontiers in Immunology, 2018; 8:1931. doi: 10.3389/fimmu.2017.01931

  5. Ben-Shaanan TL, Schiller M, Azulay-Debby H, Korin B, Boshnak N, Koren T, Krot M, Shakya J, Rahat MA, Hakim F, Rolls A. Modulation of anti-tumor immunity by the brain's reward system. Nature Communications 2018, 9(1):2723. 

  6. Simanovich E, Brod V, Rahat MA. Targeting EMMPRIN by vaccinating with a multiple antigenic peptide (161-MAP) reduces angiogenesis in a dextran sodium sulfate (DSS)-induced colitis model. Frontiers in Immunology, 2018; 9: 2919,13 pages. doi: 10.3389/fimmu.2018.02919.

  7. Simanovich E, Brod V, Rahat MM, Drazdov E, Walter M, Shakya J, and Rahat MA. Inhibition of tumor growth and metastasis by EMMPRIN multiple antigenic peptide (MAP) vaccination is mediated by immune modulation. Oncoimmunology 2017; 6(1), e1261778. DOI: 10.1080/2162402X.2016.1261778.

  8. Walter M, Simanovich E, Brod V, Lahat N, Bitterman H, and Rahat MA. An epitope-specific novel anti-EMMPRIN polyclonal antibody inhibits tumor progression. Oncoimmunology 2016; 5(2), e1078056. DOI: 10.1080/2162402X.2015.1078056.

  9. Rahat MA, Brod V, Amit-Cohen BC, Henig O, Younis S, Bitterman H. Oxygen mitigates the inflammatory response in a model of hemorrhage and zymosan induced inflammation. Shock. 2016; Feb;45(2):198-208.

  10. Rahat MA and Shakya J. Parallel aspects of the microenvironment in cancer and autoimmune diseases. Mediators of Inflammation, vol. 2016; Article ID 4375120,  2016

  11. Rahat MA and Hemmerlein B. Macrophage-tumor cell interactions regulate the function of nitric oxide. Frontiers in Vascular Physiology 2013; 4:144 (Review)

  12. Amit-Cohen BC, Rahat MM, Rahat MA. Tumor cell-macrophage interactions increase angiogenesis through secretion of EMMPRIN. Frontiers in Vascular Physiology 2013; 4:178

  13. Amir O, Spyvak I, Lavi I, Rahat MA. Changes in the monocytic subsets CD14dimCD16+ and CD14++CD16– in chronic systolic heart failure patients. Mediators of Inflammation 2012; 89(3): 201-209

  14. Rahat MA, Bitterman H, Lahat N. Molecular Mechanisms Regulating Macrophage Response to Hypoxia. Frontiers in Immunology 2011; 2:45 (Review)

  15. Lahat N, Bitterman H, Weiss-Cerem L, Rahat MA. Hypoxia increases the membranal and secreted forms of HLA-DR in endothelial cells and renders them capable of activating T cells. Transplat. Int. 2011; 24(10):1018-26

  16. Lahat N, Bitterman H, Engelmayer-Goren M, Rosenzweig D, Weiss-Cerem L, Rahat MA. Reduced TIMP-2 in hypoxia enhances angiogenesis. Am. J. Physiol. Cell physiol. 2011; 300(3): C557-C566

  17. Perske C, Lahat N, Sheffy Levine S, Bitterman H, Hemmerlein B, Rahat MA.  Loss of inducible nitric oxide synthase (iNOS) expression in the mouse renal cell carcinoma cell line RENCA is mediated by microRNA miR-146a. Am. J. Pathol. 2010; 177(4): 2046-54

  18. Lahat N, Rahat MA, Kinarty A, Weiss-Cerem L, Pinchevski, S, Bitterman H. Hypoxia enhances lysosomal TNFα degradation in peritoneal mouse macrophages.  Am. J. Physiol. Cell Physiol. 2008; 295(1): C2-C12

  19. Marom B, Rahat MA, Lahat N, Bitterman H. Native and fragmented fibronectin oppositely modulate monocyte expression of MMP-9. J. Leukocyte. Biol. 2007; 81(6):1466-1476

  20. Rahat MA, Marom B, Bitterman H, Lahat N. Hypoxia reduces the output of matrix metalloproteinase-9 (MMP-9) in monocyte by inhibiting its secretion and elevating membranal association. J. Leukocyte. Biol. 2006; 79(4): 706-718

  21. Daniliuc S, Bitterman H, Rahat MA, Kinarty A, Rosenzweig D, and Lahat N. Hypoxia inactivates inducible nitric oxide synthase in mouse macrophages by disrupting its interaction with α-actinin 4. J. Immunol. 2003; 171(6): 3225-3232

  22. Lahat N, Rahat MA, Ballan M, Weiss-Cerem L, Engelmayer M, and Bitterman H. Hypoxia reduces CD80 expression on monocytes, but enhances their LPS-stimulated TNFα secretion. J. Leukocyte. Biol.  2003; 74(2): 197-205